How does aerobic respiration in cells leads to a change in the ph of blood plasma?

As you probably already know, aerobic respiration is the process by which organisms take up O2 and convert it to CO2 and H20 with extraction of energy. So what happens to the CO2 byproduct? It goes straight back to the lungs and gets breathed out, right? Wrong!



CO2 in the blood interacts with water and gets converted to H2CO3. H2CO3 then looses a proton and becomes HCO3- (bicarbonate). HCO3- is how CO2 travels through the blood untill it gets to the lungs where it is converted back to CO2 and leaves as a gas. Now if ventilation decreases and CO2 starts to build up, bicarbonate builds up as well. All of those H+ ions coming off H2CO3 to form HCO3- cause an decrease in pH and the result is acidosis. On the other hand if too much CO2 is being removed, pH increases, acid character decreases, and the result is alkalosis. Its a delicate balance.How does aerobic respiration in cells leads to a change in the ph of blood plasma?
In aerobic tissues the utillization of glucose or fatty acids for energy results in production of CO2 by in the case of glucose the linker reaction (PDH , 2pyruvate to 2 acetyl CoA + 2CO2 ) ,and two CO2s per acetyl CoA from the isocitrate dehydrogenase reaction ( ICDH, isocitrate to alphaketoglutarate + CO2 ) and from the alphaketogltarate dehydrogenase reaction ( aKGDH, alphaketogutarate to succinyl CoA + CO2 ).For fatty acids you get only the two dehydrogenase reactions. In any case the CO2 leaves the tissues and enters the RBC is converted to carbonic acid by carbonic anhydrase then the acid ionizes to yield protons that bind to R hemoglobin and cause it to give up the oxygen , the Bohr effect ( used in aerobic oxidation by the ETS ) and bicarbonate.The bicarbonate leaves the RBC in exchange for Cl^-1..meaning the venous blood has a higher pH than arterial blood , as bicarbonate is a reasonably strong base

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